Such as, the diversion of methadone and buprenorphine from opioid agonist therapy is described being a major difficulty in a few nations around the world (see Area Synthetic opioid trafficking). Furthermore, we see a development of drop in price from 2014 to 2019 of some opioids for instance heroin, oxycodone, https://dutchcartel.eu/product-tag/order-heroin-online/