Pentobarbital will minimize the level or effect of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Sturdy CYP3A4 inducers might lower midostaurin concentrations causing decreased efficacy. pentobarbital will reduce the level or influence of armodafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknow... https://davidi198ffc2.hyperionwiki.com/user