Stroke and coronary heart attack. Plaque buildup while in the arteries can also influence the blood vessels in the guts and brain. Individuals with significant limb ischemia/Long-term limb-threatening ischemia (CLI/CLTI) in danger for creating gangrene will current with limb soreness that has progressed from intermittent claudication with exertion to Persistent rest https://sgvasculargrp.com/medical-condition/peripheral-arterial-disease/