In this article, we show that conolidine, a normal analgesic alkaloid used in classic Chinese medication, targets ACKR3, thus providing added evidence of the correlation concerning ACKR3 and soreness modulation and opening different therapeutic avenues for the treatment of Persistent discomfort. The initial asymmetric complete synthesis of conolidine was https://henryz061tjz6.thecomputerwiki.com/user